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This is surprising given the sterile laboratory environment of the interaction so that the effect of oxytocin on face-to-face interactions must be quite strong," says Zak. He also found that women in the experiment who are ovulating were significantly less likely to be trustworthy for the same signal of trust. This effect is caused by the physiologic interactions between progesterone and oxytocin, and it makes sense behaviorally: women who are, or are about to be, pregnant, need to be much more selective in their interpretation of social signals, and also need more resources than at other times.